Does folding determine protein configuration?
نویسندگان
چکیده
منابع مشابه
Protein folding: Does diffusion determine the folding rate?
A major question about protein folding is whether the coming together by diffusion of different segments of the polypeptide chain is rate-determining. This seemingly simple question has been very difficult to answer experimentally, but a positive result has now been obtained with one small model protein.
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Proteins are synthesized in the cell as sequential strings of amino acids. However, ribosome-emerging polypeptide chains are not active and they have to fold into a usually unique three-dimensional (3D) structure to become functional. Many proteins have been shown to attain spontaneously in vitro their native state from an initially complex ensemble of unfolded conformations in the absence of t...
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Recent studies in protein folding suggest that native state topology plays a dominant role in determining the folding mechanism, yet an analogous statement has not been made for RNA, most likely due to the strong coupling between the ionic environment and conformational energetics that make RNA folding more complex than protein folding. Applying a distributed computing architecture to sample ne...
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Lali sub-surface structure, with a NW-SE Zagros trending is located in Dezful Embayment. To determine the folding mechanism, structural geometric parameters including limbs dip, amplitude, wavelength, and crestal length were determined in four stages during deformation. In order to investigate the lateral folding mechanism, these geometric parameters were analyzed in three parts in the Lal...
متن کاملNative contacts determine protein folding mechanisms in atomistic simulations.
The recent availability of long equilibrium simulations of protein folding in atomistic detail for more than 10 proteins allows us to identify the key interactions driving folding. We find that the collective fraction of native amino acid contacts, Q, captures remarkably well the transition states for all the proteins with a folding free energy barrier. Going beyond this global picture, we devi...
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ژورنال
عنوان ژورنال: Nature
سال: 1994
ISSN: 0028-0836,1476-4687
DOI: 10.1038/370013a0